Reprogramming immune cells to fight glioblastoma
Targeting macrophage reprogramming in glioblastoma
Trying ways to change immune cells called macrophages so they help adults with glioblastoma fight their tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11145262 on NIH RePORTER |
What this research studies
This project focuses on tumor-associated macrophages, immune cells in glioblastoma that often support tumor growth, and a receptor called GPR183 found on those cells. Researchers will use tumor samples, cell cultures, and animal models to see how GPR183 affects macrophage behavior and how reprogrammed macrophages influence tumors. They will test drugs or other methods to push macrophages toward an anti-tumor state and study how that changes tumor progression. Promising approaches could be advanced toward clinical testing in patients.
Who could benefit from this research
Good fit: Adults with glioblastoma, especially those undergoing surgery or willing to donate tumor tissue or blood samples, would be most relevant for participation or sample donation.
Not a fit: People with other types of brain tumors, children, or patients who cannot provide tumor or blood samples are unlikely to benefit directly from this specific work.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reprogram immune cells to slow tumor growth and improve responses to other glioblastoma therapies.
How similar studies have performed: Laboratory studies have shown that reprogramming tumor macrophages can slow tumor growth in models, but targeting the GPR183 receptor is a novel and largely untested approach.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Chen, Peiwen — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Chen, Peiwen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.