Regulation of vascular muscle cell identity by TEADs in adult arteries
Official title: Regulation of vascular smooth muscle phenotype by TEADs
Funded at Louisiana State Univ Hsc Shreveport · NIH-11451008 · Data updated 2026-11-12
A study to understand how TEAD family proteins help keep vascular smooth muscle cells in their healthy, contractile state in adult arteries and how this may relate to a dangerous artery condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | September 20, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $708,741 |
| NIH project number | 1R01HL176881-01A1 |
| Project ID | NIH-11451008 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with ASCVD or aortic/artery diseases could indirectly benefit from insights that improve vascular health or guide future therapies.
✕Less likely to help
People without vascular disease may not directly benefit, as the study is focused on vascular cell regulation.
What this research studies
This project looks at how TEAD proteins help vascular smooth muscle cells stay in their contractile state, which keeps arteries stable. Scientists will analyze public single-cell datasets from human and mouse arteries and use a special mouse model to study what happens when TEAD1 and TEAD3 are removed in vascular cells. They will map where TEAD3 binds in the genome to identify genes that control muscle contraction and how inflammation may be involved. The work includes creating a new AVI-tagged TEAD3 mouse to enable in vivo analysis of TEAD3 interactions.
Why it matters
Potential benefit: Understanding TEADs could reveal targets to prevent or treat occlusive artery diseases like aortic aneurysm and other vascular conditions.
How similar studies have gone: Prior work shows that TEAD family members can regulate vascular cell states, and this study builds on those findings with in vivo models and genome-wide mapping.
Where this research is happening
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Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Zhou, Jiliang — Louisiana State Univ Hsc Shreveport
- Study coordinator: Zhou, Jiliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.