Regulation of TRPM7 in low and high magnesium conditions
Official title: Regulation of TRPM7 channel kinase under hypo and hypermagnesemic conditions.
Funded at Wright State University · NIH-11444919 · Data updated 2026-11-12
This grant studies how the TRPM7 ion channel and enzyme influence immune cell function when magnesium levels change, which could affect immune responses in people.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wright State University NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project start | September 2, 2026 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $540,878 |
| NIH project number | 1R15AI202918-01 |
| Project ID | NIH-11444919 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal for patients with immune or muscle disorders related to magnesium imbalance or those at risk of magnesium deficiency.
✕Less likely to help
Patients without magnesium-related immune issues or kidney disease may see limited direct benefit.
What this research studies
The project focuses on how magnesium and calcium signals control T cells and macrophages, and how TRPM7’s dual channel-kinase role contributes to immune health. By using a new mouse model and cellular assays, researchers will separate the ion transport and kinase activities to understand their individual effects. The goal is to reveal mechanisms that may underlie immune-related issues seen when magnesium balance is disrupted. This could guide future strategies to support immune function in patients with magnesium deficiencies or related kidney problems.
Why it matters
Potential benefit: Understanding TRPM7’s roles could lead to better approaches to support immune function in people with magnesium imbalances or kidney disease.
How similar studies have gone: Previous work shows TRPM7 is essential for T-cell development and macrophage activation, supporting a translational path for this research.
Where this research is happening
-
Wright State University
Dayton, United States Active
Researchers
- Principal investigator: Kozak, Juliusz Ashot — Wright State University
- Study coordinator: Kozak, Juliusz Ashot
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.