Regulation and role of pDCs in HBV/HIV coinfection immune problems
Official title: Regulation and Role of pDC in Immunopathogenesis of HBV/HIV co-Infection
Funded at University of Maryland Baltimore · NIH-11473256 · Data updated 2026-11-12
This grant studies how a special type of immune cell called pDCs interacts with HIV and HBV in coinfected people to shape immune responses and liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $617,553 |
| NIH project number | 1R01DK149875-01 |
| Project ID | NIH-11473256 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV and/or chronic HBV infection who could participate in future human studies or trials related to immune therapies for HBV.
✕Less likely to help
Patients without HIV or HBV infection may not directly benefit from these findings.
What this research studies
Researchers will use humanized mouse models that carry human liver and immune cells to study how HIV coinfection affects anti-HBV immunity and liver inflammation. They will compare HBV infection with and without HIV coinfection to uncover immune dysregulation and disease pathways. A new mouse model with autologous human immune and liver cells will be developed to better mimic human coinfection. Findings could guide new therapies aimed at restoring immune responses against HBV in people who also have HIV.
Why it matters
Potential benefit: If successful, the work could lead to therapies that improve immune control of HBV in people with HIV, potentially reducing liver damage.
How similar studies have gone: Prior work with humanized mouse models has shown promise in studying HBV/HIV interactions, but this project advances more human-like models and mechanisms.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Su, Lishan — University of Maryland Baltimore
- Study coordinator: Su, Lishan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.