Regulating hormone signaling through Gsα expression control
Official title: Control of allelic Gsα expression for regulating hormone signaling
Funded at Massachusetts General Hospital · NIH-10941975 · Data updated 2026-11-12
This study is looking at how a protein important for hormone signaling works differently in various tissues, especially in relation to bone health, and it aims to help people with hormone-related issues like pseudohypoparathyroidism type-1A by finding new ways to improve their treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 2, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $553,545 |
| NIH project number | 1R01DK140244-01 |
| Project ID | NIH-10941975 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with pseudohypoparathyroidism type-1A or related conditions that affect hormone signaling.
✕Less likely to help
Patients without any genetic mutations affecting Gsα expression or those with unrelated hormone disorders may not benefit from this research.
What this research studies
This research investigates how the expression of the Gsα protein, which is crucial for hormone signaling, is controlled in different tissues. It focuses on understanding the differences in Gsα expression from maternal and paternal alleles, particularly in cells that are important for bone and hormone function. By using advanced techniques like CRISPR, the study aims to uncover how these mechanisms affect conditions such as pseudohypoparathyroidism type-1A, which leads to hormone signaling deficiencies and related symptoms. Patients may benefit from insights that could lead to new treatments or management strategies for hormone-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with hormone signaling disorders and skeletal development issues.
How similar studies have gone: Previous research has shown promising results in understanding Gsα signaling and its implications in related disorders, indicating that this approach has potential for success.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Bastepe, Murat — Massachusetts General Hospital
- Study coordinator: Bastepe, Murat
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.