Recovery patterns in acute disorders of consciousness from brain injury
Official title: Phenotypes and Endotypes of Recovery from Acute Disorders of Consciousness
Funded at Vanderbilt University Medical Center · NIH-11425202 · Data updated 2026-11-12
This NIH grant tests whether a mix of brain scans, blood markers, and behavioral data can predict when people with acute brain injuries regain the ability to communicate.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 15, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $711,408 |
| NIH project number | 1R01NS150580-01 |
| Project ID | NIH-11425202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute disorders of consciousness due to traumatic brain injury, stroke, anoxia, or other acute brain injuries admitted to participating ICUs.
✕Less likely to help
Patients with stable, long-standing consciousness or who do not have an opportunity for recovery may not benefit.
What this research studies
If you or a family member has an acute disorder of consciousness after a brain injury, this study follows you in intensive care and after discharge to see which biological signals and test results best forecast regaining communication. Researchers will collect behavioral data, blood biomarkers, MRI/EEG results, and other measurements over six ICUs at Vanderbilt and during long-term follow-up to build a prediction model. The goal is to provide clearer prognostic information to families and clinicians and to tailor care plans based on individual recovery trajectories.
Why it matters
Potential benefit: If successful, the study could help clinicians predict recovery better and guide decisions about treatment and rehabilitation.
How similar studies have gone: Previous work suggests promising links between multimodal data and recovery, but this project advances toward integrated predictive models.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Bodien, Yelena G — Vanderbilt University Medical Center
- Study coordinator: Bodien, Yelena G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.