Reactome: An Open Knowledgebase of Human Pathways
Official title: Reactome: An Open Knowledgebase of Human Pathways.
Funded at Ontario Institute for Cancer Research · NIH-11420528 · Data updated 2026-11-12
A global, open access database of human biological pathways helps researchers and clinicians understand cancer biology and discover new ideas for treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ontario Institute for Cancer Research NIH-funded |
| Lab location | 1 site (Toronto, Canada) |
| Project start | August 18, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,145,778 |
| NIH project number | 5U24HG012198-05 |
| Project ID | NIH-11420528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient population; the grant supports a data/resource backbone used by many researchers including those studying cancers.
✕Less likely to help
Direct patient benefit is indirect; the resource serves the research community rather than individuals directly.
What this research studies
Reactome is a freely accessible, manually curated knowledgebase that maps human biological pathways, supported by peer review and evidence from primary literature. It provides standardized descriptions and tools to interpret large omics datasets, aiding researchers in genomics, proteomics, and systems biology. This renewal supports ongoing curation, updates, and interoperability with other resources to accelerate discoveries in cancer biology and drug development.
Why it matters
Potential benefit: If successful, this knowledgebase will help researchers and clinicians better interpret omics data and design more informed cancer research and therapeutic strategies.
How similar studies have gone: The Reactome platform has an established track record with broad uptake and ongoing community use, though ongoing updates are needed for current cancer biology insights.
Where this research is happening
-
Ontario Institute for Cancer Research
Toronto, Canada Active
Researchers
- Principal investigator: Stein, Lincoln D. — Ontario Institute for Cancer Research
- Study coordinator: Stein, Lincoln D.
Related research
Other NIH-funded projects on the same topics.
-
Overture cancer genomics data hub
This project builds an open, easy-to-use system to store, share, and explore tumor gene data for researchers and clinicians.
-
A platform for managing cancer genomic data
Overture is a friendly tool that helps researchers easily store, explore, and share important cancer gene information, making it simpler for them to understand and analyze the data they need to fight cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.