Overture cancer genomics data hub
Official title: Overture: A Multi-Scale Data Platform for Cancer Genomics Research
Funded at Ontario Institute for Cancer Research · NIH-11163216 · Data updated 2026-11-12
This project builds an open, easy-to-use system to store, share, and explore tumor gene data for researchers and clinicians.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ontario Institute for Cancer Research NIH-funded |
| Lab location | 1 site (Toronto, Canada) |
| Project start | September 9, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $537,348 |
| NIH project number | 5U24CA253529-05 |
| Project ID | NIH-11163216 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with cancer who are willing to contribute their tumor genomic data or allow their clinical genomic results to be included in research databases are the most relevant participants for this work.
✕Less likely to help
Patients who do not have genomic testing or who do not contribute their data are unlikely to see direct benefits from this project.
What this research studies
As a patient, this project builds Overture, an open-source system to help researchers store and manage very large cancer gene datasets. The team will deliver a turnkey Data Management System that can run locally or in the cloud, suitable for small labs up to large consortia. They will add a framework so visualization and analysis apps can plug into the system and will strengthen data access controls to protect privacy. Over five years the project aims to package, extend, and deploy these tools so researchers can more easily share and analyze tumor genomic data.
Why it matters
Potential benefit: If successful, this could speed discovery of new cancer biomarkers and treatments by making tumor genomic data easier to share and analyze.
How similar studies have gone: Similar cancer data platforms (for example TCGA and other genomic repositories) have helped fuel discoveries, and Overture builds on that experience with new integration and visualization features.
Where this research is happening
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Ontario Institute for Cancer Research
Toronto, Canada Active
Researchers
- Principal investigator: Yung, Christina — Ontario Institute for Cancer Research
- Study coordinator: Yung, Christina
Related research
Other NIH-funded projects on the same topics.
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Reactome: An Open Knowledgebase of Human Pathways
A global, open access database of human biological pathways helps researchers and clinicians understand cancer biology and discover new ideas for treatment.
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A platform for managing cancer genomic data
Overture is a friendly tool that helps researchers easily store, explore, and share important cancer gene information, making it simpler for them to understand and analyze the data they need to fight cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.