Quick identification of fungal infections and their treatment resistance
Rapid fungal identification and antifungal susceptibility testing through quantitative, multiplexed RNA detection
This study is working on a new, faster way to test for fungal infections so that patients can get the right treatment quickly, helping them feel better and stay safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10874666 on NIH RePORTER |
What this research studies
This research focuses on developing rapid diagnostic tests for fungal infections, which are increasingly common and can be deadly. By utilizing advanced RNA detection techniques, the study aims to quickly identify the specific fungus causing an infection and determine its resistance to antifungal medications. This approach seeks to replace outdated methods that take days, thereby allowing for timely and effective treatment decisions. Patients will benefit from faster diagnoses, which can lead to improved outcomes and reduced mortality rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with suspected invasive fungal infections, particularly those at high risk due to underlying health conditions.
Not a fit: Patients with non-fungal infections or those who do not exhibit symptoms of fungal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce mortality rates from invasive fungal infections by enabling timely and effective treatment.
How similar studies have performed: Previous research has shown success in rapid diagnostics for bacterial infections using similar RNA detection methods, indicating potential for success in fungal diagnostics as well.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Bhattacharyya, Roby Paul — Broad Institute, INC.
- Study coordinator: Bhattacharyya, Roby Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.