Quick detection of germs causing sepsis from blood samples
Rapid Culture-Independent Detection of Sepsis Causing Microorganism Directly from Blood
['FUNDING_OTHER'] · UNIVERSITY OF MASSACHUSETTS AMHERST · NIH-11126801
This study is testing a new, quicker way to find out which germs are causing sepsis from blood samples, so doctors can start the right treatment much faster—within about two hours—helping patients get better sooner.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MASSACHUSETTS AMHERST (nih funded) |
| Locations | 1 site (HADLEY, UNITED STATES) |
| Trial ID | NIH-11126801 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a fast and accurate method to identify the microorganisms that cause sepsis directly from blood samples, without the need for traditional blood cultures. By utilizing advanced nanopore and click-chemistry techniques, the goal is to provide results in about two hours, significantly reducing the time it takes to start appropriate antibiotic treatment. This approach aims to improve patient outcomes by allowing for timely and targeted therapy, which is crucial in managing sepsis effectively. The study will incorporate automated sample preparation and assay methods to streamline the process.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized patients who are showing signs of severe sepsis.
Not a fit: Patients who are not hospitalized or do not exhibit symptoms of sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to faster and more precise treatment for patients with sepsis, potentially reducing mortality rates.
How similar studies have performed: Previous research has shown promise in using molecular diagnostic technologies for pathogen identification, but this approach aims to innovate beyond existing methods.
Where this research is happening
HADLEY, UNITED STATES
- UNIVERSITY OF MASSACHUSETTS AMHERST — HADLEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, CHANG — UNIVERSITY OF MASSACHUSETTS AMHERST
- Study coordinator: LIU, CHANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, bacterial disease treatment, Bacterial Infections, bacterial infectious disease treatment