Pulmonary host responses in melioidosis
Official title: RP2: Pulmonary host responses in human melioidosis
Funded at University of Texas Med Br Galveston · NIH-11602460 · Data updated 2026-11-12
This grant studies how the human lungs fight a serious bacterial lung infection called melioidosis and aims to develop targeted treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | September 1, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $7,998 |
| NIH project number | 3P01AI199402-01S1 |
| Project ID | NIH-11602460 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with melioidosis, especially those with pulmonary involvement, may be eligible for future translational efforts or related studies.
✕Less likely to help
Patients without melioidosis or with non-pulmonary disease may not directly benefit.
What this research studies
The project focuses on how Burkholderia pseudomallei causes pneumonia and why some patients have worse outcomes. Researchers will use data from patients, including blood and lung samples, plus analyses of bacterial genomes and human lung cells to understand the immune response. The goal is to uncover which lung defenses break down and how to boost them with new therapies. By studying primary human lung cells and multi-omic data, the work connects patient biology to potential treatments.
Why it matters
Potential benefit: If successful, the research could lead to targeted therapies that improve survival and lung function for people with melioidosis.
How similar studies have gone: Preliminary lines of evidence in humans and multi-omic profiling have shown promise in understanding pulmonary melioidosis, supporting further exploration.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Torres, Alfredo G — University of Texas Med Br Galveston
- Study coordinator: Torres, Alfredo G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.