Protein Clues for Autism Spectrum Disorders
Proteogenetics of Autism Spectrum Disorders
This project looks at proteins in cells from patients with autism spectrum disorder to understand what causes their symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11146714 on NIH RePORTER |
What this research studies
This project uses cells donated by patients with autism spectrum disorder (ASD) to learn more about the condition. Researchers will grow these cells in the lab to create models that mimic brain tissue, allowing them to study how proteins change in individual cells. By focusing on specific genetic changes linked to ASD, like those found in Rett Syndrome, the team hopes to uncover the basic molecular problems that lead to ASD symptoms. This work aims to shed light on the underlying biology of ASD, which has been difficult to study directly in the human brain.
Who could benefit from this research
Good fit: Patients with autism spectrum disorder, particularly those with known genetic mutations like those causing Rett Syndrome, are relevant to this research.
Not a fit: Patients without a diagnosis of autism spectrum disorder or related genetic conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could reveal new biological pathways involved in autism spectrum disorder, potentially leading to new ways to diagnose or treat the condition.
How similar studies have performed: While the use of patient-derived iPSCs and organoids for proteomic studies in brain diseases is a cutting-edge approach, previous genetic studies have identified risk factors for ASD.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Yates Iii, John R — Scripps Research Institute, the
- Study coordinator: Yates Iii, John R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.