Protein C system in trauma-related blood-clotting and inflammation
Official title: The role of the protein C system in trauma induced coagulopathy and thromboinflammation: mechanisms and targeted therapy.
Funded at University of Colorado Denver · NIH-11380019 · Data updated 2026-11-12
A study aiming to understand how the protein C system affects blood clotting and inflammation after severe injuries and to explore targeted therapies for trauma patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $619,024 |
| NIH project number | 5R01HL182062-02 |
| Project ID | NIH-11380019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and adolescents with severe trauma at risk for TIC and thromboinflammation who may benefit from therapies modulating the protein C pathway.
✕Less likely to help
Patients with trauma who do not exhibit protein C–related dysregulation or those with contraindications to anticoagulant-like therapies may not benefit.
What this research studies
This project looks at how the protein C pathway contributes to coagulation problems and inflammation after trauma and whether therapies targeting this pathway could improve outcomes. By studying cellular and animal models and using patient-derived samples, the team hopes to uncover precise mechanisms driving TIC and thromboinflammation. The goal is to identify potential treatments that can modulate the protein C system to reduce organ injury and death after trauma. Findings could inform future clinical approaches to tailor resuscitation and anticoagulant strategies for injured patients. The work is led by the University of Colorado Denver, with a focus on translating mechanistic insights into safer, more effective care for trauma patients.
Why it matters
Potential benefit: If successful, the research could lead to targeted therapies that reduce bleeding complications and inflammatory damage in trauma patients, potentially saving lives and improving recovery.
How similar studies have gone: Previous work suggests targeting coagulation pathways can influence outcomes in trauma, but direct therapeutics for the protein C system in TIC are still emerging.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Cohen, Mitchell — University of Colorado Denver
- Study coordinator: Cohen, Mitchell
Related research
Other NIH-funded projects on the same topics.
-
Integrative histo-genomic analysis to guide cancer risk and targeted therapies with interpretable AI
Researchers are developing an advanced AI-powered approach to map genetic and cellular patterns across breast and cervical cancers to help tailor treatments.
-
Targeted therapy for AML using DHODH inhibitors to boost differentiation and immune response
Aims to help adults with acute myeloid leukemia by using a special drug approach that makes cancer cells act more like normal blood cells and supports the immune system.
-
Adipome biomarkers in obese TNBC mice for targeted therapy
A study in mice explores how fat-derived particles called adipomes influence an aggressive breast cancer type, with the goal of guiding personalized therapies.
-
Enhancing HER2-targeted therapy for resistant breast cancer
This grant explores new ways to overcome resistance to HER2-targeted therapy in people with HER2-positive breast cancer.
-
Metabolic imaging to guide targeted therapy for liver cancer
A clinician-scientist at UPenn is pursuing training to use metabolic imaging to tailor therapy for hepatocellular carcinoma.
-
Targeted therapy for splicing-factor mutant myeloid cancers
Aims to test a dual drug strategy targeting ATR and PARP pathways in adults with splicing-factor mutant acute myeloid leukemia or related myeloid diseases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.