Protective immunity after dengue infections and vaccination
Official title: Protective immunity following dengue virus natural infections and vaccination
Funded at University of California Berkeley · NIH-11415532 · Data updated 2026-11-12
Researchers are studying how our immune system remembers dengue and how vaccines influence that protection, aiming to spot clues that predict who remains protected or at risk after infection or vaccination.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | July 29, 2015 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,953,022 |
| NIH project number | 5P01AI106695-12 |
| Project ID | NIH-11415532 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with a history of dengue infection or recipients of dengue vaccination, across diverse age groups and geographic settings.
✕Less likely to help
People without dengue exposure or vaccination history may not directly benefit from the immune biomarker discoveries.
What this research studies
This project follows people who have dengue infections or received dengue vaccines to understand how antibodies, B cells, and T cells develop and behave. It uses advanced lab methods and clinical data to identify biomarkers that indicate protection or risk of enhanced disease with different dengue serotypes. The goal is to map the immune signatures that best predict safe, lasting immunity and to inform better vaccines and public-health strategies. The work builds on a large, ongoing collaboration and shares findings with health agencies to guide regulatory decisions.
Why it matters
Potential benefit: If successful, the research could lead to clearer biomarkers of protection and improved dengue vaccines, reducing severe disease and outbreaks.
How similar studies have gone: Previous work in dengue immunity has yielded important insights and this project expands on that foundation with new tools and hypotheses; several high-impact publications have emerged.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Harris, Eva — University of California Berkeley
- Study coordinator: Harris, Eva
Related research
Other NIH-funded projects on the same topics.
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Protective dengue vaccines that steer T and B cell responses
A vaccine study aims to guide the body’s T and B cells to fight all four dengue virus types safely and effectively.
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How the immune system responds to dengue vaccines and infection
This project compares immune reactions in people given different dengue vaccine formulations to find why one vaccine fully prevented DENV-2 infection while another did not.
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How prior dengue infections shape T cell responses after a new infection or vaccine
This project looks at how a person’s existing dengue immunity affects their body's T cell response when exposed to a different dengue serotype or a live dengue vaccine, with a focus on kids and how this influences protection and safety.
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Dengue vaccine-B cell and T cell responses linked to protection after controlled dengue infection
A Johns Hopkins-led study will look at how the body’s B and T cells respond to dengue vaccines and how these responses relate to protection against dengue infection in people who participate in a controlled infection model.
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How long dengue vaccine protection lasts in areas where dengue is common
This project looks at immune responses after dengue vaccination to find which people keep protection longest in places where dengue is common.
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How past dengue infection or vaccination shapes T cell immunity
This project looks at how previous dengue infections or a weakened dengue vaccine change T cells in children and others exposed to dengue.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.