Protecting Lungs from Oxygen Damage with B Cells
Protective role of B cells in hyperoxic lung injury
This research explores how special immune cells called B cells might protect the lungs of critically ill patients who need high levels of oxygen.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11140516 on NIH RePORTER |
What this research studies
Critically ill patients, especially those with severe lung conditions like ARDS, often need high levels of oxygen to breathe. However, too much oxygen can sometimes cause more lung damage and inflammation. This project looks at how certain immune cells, called B cells, might help protect the lungs from this damage. Researchers are studying if increasing B cell numbers in the lungs could reduce inflammation and improve lung health during oxygen treatment.
Who could benefit from this research
Good fit: This foundational research is for patients with acute lung injury or ARDS who require high oxygen levels and could benefit from future therapies that protect their lungs.
Not a fit: Patients who do not have acute lung injury or ARDS, or who do not require high oxygen therapy, would not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to protect the lungs of critically ill patients receiving high oxygen, potentially reducing complications from conditions like ARDS.
How similar studies have performed: This research explores a novel approach by focusing on the protective role of B cells in hyperoxic lung injury, building on recent discoveries in animal models.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hanidziar, Dusan — Massachusetts General Hospital
- Study coordinator: Hanidziar, Dusan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.