Preventing the build-up of calcium in blood vessels for kidney disease patients
Official title: Preventing vascular calcification in kidney disease
Funded at University of Kansas Medical Center · NIH-11103139 · Data updated 2026-11-12
This study is looking at how to stop harmful calcium build-up in the blood vessels of people with chronic kidney disease, and it will test a special treatment called ASARM to see if it can help keep your blood vessels healthy and improve kidney function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | June 5, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $532,671 |
| NIH project number | 5R01HL167073-02 |
| Project ID | NIH-11103139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly those experiencing vascular calcification.
✕Less likely to help
Patients with acute kidney injury or those without any signs of vascular calcification may not benefit from this research.
What this research studies
This research investigates how to prevent vascular calcification, a serious complication in patients with chronic kidney disease (CKD). It focuses on understanding the role of calciprotein particles (CPPs) in the calcification process and how a specific peptide, ASARM, may help inhibit this harmful build-up. By studying CKD patients and animal models, the research aims to determine if synthetic ASARM peptides can effectively reduce vascular calcification and improve kidney function. Patients may be involved in trials to test the effectiveness of this treatment.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce vascular calcification and improve health outcomes for kidney disease patients.
How similar studies have gone: Previous studies have shown promising results in using peptides to inhibit vascular calcification, suggesting potential for success in this approach.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Rowe, Peter S — University of Kansas Medical Center
- Study coordinator: Rowe, Peter S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.