Preventing skin cancer by targeting survival signals in cells
Targeting aberrant anti-apoptotic signaling for prevention of skin cancer
This study is looking for a way to stop squamous cell carcinoma, a type of skin cancer, by blocking certain signals that help cancer cells survive, while keeping healthy skin cells safe, so that we can find a gentler treatment that might prevent cancer from getting worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10830394 on NIH RePORTER |
What this research studies
This research focuses on preventing nonmelanoma skin cancer, particularly squamous cell carcinoma, by targeting specific signaling pathways that allow cancer cells to survive. The approach involves inhibiting proteins that contribute to the abnormal survival of these cancer cells while leaving normal skin cells unharmed. By understanding the mechanisms behind this survival signaling, the researchers aim to develop a treatment that minimizes side effects and reduces the need for invasive surgical procedures. This could provide a new way to intervene before cancer develops or progresses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for developing squamous cell carcinoma, particularly those with a history of significant UV exposure.
Not a fit: Patients with advanced or metastatic skin cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less invasive treatments for preventing skin cancer.
How similar studies have performed: Other research has shown promise in targeting survival pathways in cancer cells, suggesting that this approach could be effective.
Where this research is happening
Omaha, United States
- Creighton University — Omaha, United States (Active)
Researchers
- Principal investigator: Hansen, Laura a — Creighton University
- Study coordinator: Hansen, Laura a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.