Preventing severe complications after bone marrow transplants
Preventing GVHD by inhibition of alloantigen presentation in the gut
This study is looking at ways to stop graft-versus-host disease (GVHD), a serious issue that can happen after bone marrow transplants, by understanding how certain immune cells in the gut might cause it, so we can find better ways to protect patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10893474 on NIH RePORTER |
What this research studies
This research investigates how to prevent graft-versus-host disease (GVHD), a serious complication that can occur after bone marrow transplants. The team will explore the role of specific immune cells in the gut that may trigger this condition. By using advanced techniques like ATAC sequencing and single-cell analysis, they aim to identify pathways that could be targeted to reduce the risk of GVHD. This work combines laboratory studies with clinical data to ensure findings are relevant to patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing allogeneic bone marrow transplantation, particularly those at high risk for developing GVHD.
Not a fit: Patients who are not undergoing bone marrow transplantation or those with conditions unrelated to GVHD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for GVHD, enhancing the safety and outcomes of bone marrow transplants.
How similar studies have performed: Previous research has shown promise in understanding GVHD mechanisms, but this specific approach focusing on gut antigen presentation is relatively novel.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Hill, Geoffrey Roger — Fred Hutchinson Cancer Center
- Study coordinator: Hill, Geoffrey Roger
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.