NIH-funded research NIH-funded research

Preventing opioid use in youth transitioning to adulthood

Official title: Preventing Opioid Use Among Justice-Involved Youth as They Transition to Adulthood: Leveraging Safe Adults (LeSA)

Funded at Texas Christian University · NIH-10209094 · Data updated 2026-11-12

This study is looking at how to help young people who have been in the juvenile justice system avoid misusing opioids as they grow up, by training their parents or guardians in supportive ways to manage behavior and promote emotional health.

More Opioid Use research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionTexas Christian University
NIH-funded
Lab location1 site (Fort Worth, United States)
Project startSeptember 30, 2019
Project endAugust 31, 2025
Funding year2020
Award (this year)$4,460,305
NIH project number4UH3DA050250-02
Project IDNIH-10209094 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adolescents aged 16-18 who are transitioning out of juvenile justice facilities and are at risk for substance use.

Less likely to help

Patients who are not involved in the juvenile justice system or who are not at risk for opioid misuse may not benefit from this research.

What this research studies

This research focuses on preventing opioid misuse among youth who have been involved in the juvenile justice system as they transition to adulthood. It aims to adapt a relational intervention called Trust-based Relational Intervention® (TBRI®) to help these vulnerable adolescents by training safe adults, such as parents or guardians, in effective behavior management techniques. The goal is to promote emotional regulation and support these youth in avoiding substance use as they reintegrate into their communities after detention. By addressing the unique challenges faced by this population, the research seeks to reduce the risk of opioid misuse and related disorders.

Why it matters

Potential benefit: If successful, this research could significantly reduce the rates of opioid misuse among at-risk youth, leading to healthier transitions into adulthood.

How similar studies have gone: Previous research has shown success in using relational interventions to support at-risk youth, indicating a promising approach for this population.

Where this research is happening

  • Texas Christian University
    Fort Worth, United States
    Active

Researchers

  • Principal investigator: Knight, Danica K — Texas Christian University
  • Study coordinator: Knight, Danica K

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.