Preventing opioid use disorder in at-risk individuals
Official title: CTN-139 - Subthreshold Opioid Use Disorder Prevention (CoCare)
Funded at Oregon Health & Science University · NIH-11295202 · Data updated 2026-11-12
This study is all about helping people who might be at risk of developing problems with opioid use by offering them support, education, and resources to keep them healthy and prevent those issues from getting worse.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $314,465 |
| NIH project number | 3UG1DA015815-24S1 |
| Project ID | NIH-11295202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals who exhibit early signs of opioid use disorder or are at risk due to various factors such as previous substance use or environmental influences.
✕Less likely to help
Patients who are already diagnosed with opioid use disorder or those who do not exhibit any risk factors for developing the disorder may not benefit from this research.
What this research studies
This research focuses on preventing the development of opioid use disorder in individuals who may be at risk. It employs a community-based approach to identify and support those with subthreshold symptoms of opioid use disorder, providing them with resources and interventions to reduce their risk. The program aims to engage participants through education, counseling, and support services tailored to their needs. By addressing the issue early, the research seeks to mitigate the potential progression to full-blown opioid use disorder.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of opioid use disorder among at-risk populations.
How similar studies have gone: Previous research has shown that early intervention programs can effectively prevent the progression of substance use disorders, indicating a promising approach for this initiative.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Korthuis, Philip Todd — Oregon Health & Science University
- Study coordinator: Korthuis, Philip Todd
Related research
Other NIH-funded projects on the same topics.
-
Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)
A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.
-
Precise epigenetic drugs for opioid addiction
A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
-
Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
-
Optimizing long-acting PrEP and opioid treatment for people in jails and prisons
This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.
-
Scaling up medications for opioid use disorder in residential treatment programs
This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.
-
Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN
This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.