Preventing graft-versus-host disease using immune cells
In Vivo Prevention of Murine GVHD
['FUNDING_R37'] · UNIVERSITY OF MINNESOTA · NIH-10866573
This study is looking at whether giving special immune cells from donors can help prevent a serious condition called graft-versus-host disease (GVHD) in people who have had a bone marrow transplant, especially after treatments like chemotherapy or radiation.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10866573 on ClinicalTrials.gov |
What this research studies
This research focuses on preventing graft-versus-host disease (GVHD), a serious complication that can occur after bone marrow transplants. It investigates the role of a specific type of immune cell, known as innate lymphoid type 2 cells (ILC2s), which have anti-inflammatory properties and can help repair tissues. The researchers aim to determine if infusing these donor ILC2s can reduce the incidence or severity of GVHD in mice, particularly after treatments like total body irradiation or chemotherapy. By understanding how these cells interact with intestinal stem cells, the study seeks to develop new strategies for improving patient outcomes following bone marrow transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are undergoing or have undergone bone marrow transplantation and are at risk for developing GVHD.
Not a fit: Patients who are not undergoing bone marrow transplantation or those who do not have a risk of GVHD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of GVHD in patients undergoing bone marrow transplants.
How similar studies have performed: Previous research has shown promise in using immune cells for similar therapeutic approaches, indicating potential for success in this area.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLAZAR, BRUCE R — UNIVERSITY OF MINNESOTA
- Study coordinator: BLAZAR, BRUCE R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Graft Versus Host Disease