Prenatal gene curation panel for severe birth defects and pregnancy loss
Official title: Prenatal Gene Curation Expert Panel for Severe Structural Anomalies and Stillbirth
Funded at Baylor College of Medicine · NIH-11335170 · Data updated 2026-11-12
A team at Baylor College of Medicine is continuing work to clarify which genes cause severe prenatal problems and pregnancies lost, so doctors can better diagnose and manage these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $378,565 |
| NIH project number | 2U24HD104588-04A1 |
| Project ID | NIH-11335170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Families dealing with severe fetal anomalies, stillbirth, or recurrent pregnancy loss, and clinicians interpreting prenatal genetic results.
✕Less likely to help
Patients without prenatal genetic concerns or a clear gene-disease link may not benefit directly.
What this research studies
This NIH grant funds a panel of experts who review and validate the link between specific genes and severe fetal anomalies, non-immune fetal hydrops, stillbirth, and recurrent pregnancy loss. The effort leverages clinical data, prenatal imaging, and genomic information to determine which gene-disease relationships are solid enough to guide care. The work aims to improve interpretation of prenatal genetic tests and support future prenatal treatment options. This is a collaborative, expert-curation project designed to translate genomic findings into clearer clinical action during pregnancy.
Why it matters
Potential benefit: If successful, it could lead to more accurate prenatal diagnoses and better-informed decisions for families affected by severe fetal conditions.
How similar studies have gone: Similar gene-curation efforts have improved clarity around prenatal gene-disease relationships and informed clinical guidelines.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Van Den Veyver, Ignatia B — Baylor College of Medicine
- Study coordinator: Van Den Veyver, Ignatia B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.