Predictive learning and brain signals in schizophrenia
Official title: State- and Trait-like Perceptual Predictive Learning Abnormalities in Schizophrenia
Funded at University of Manitoba · NIH-11216859 · Data updated 2026-11-12
A study using EEG to understand how people with schizophrenia form beliefs from sounds, which may help explain and treat auditory hallucinations.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Manitoba NIH-funded |
| Lab location | 1 site (Winnipeg, Canada) |
| Project start | July 1, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $191,910 |
| NIH project number | 1R21MH141610-01 |
| Project ID | NIH-11216859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with schizophrenia, including those with active auditory hallucinations, who can complete EEG sessions over six months.
✕Less likely to help
Healthy individuals or people with schizophrenia unable to participate in follow-up EEG assessments may not benefit.
What this research studies
This project will use EEG to look at how people with schizophrenia process sounds and update their beliefs about what they hear. It will follow 90 adults with schizophrenia (including 60 who have auditory hallucinations) and 30 healthy comparison participants over six months, with three assessments. The goal is to link neural patterns of predictive learning to specific symptoms and cognitive features, guiding future interventions.
Why it matters
Potential benefit: If successful, findings could inform brain-based targets for therapies to reduce hallucinations and cognitive difficulties.
How similar studies have gone: Previous work suggests abnormal predictive learning is related to symptoms; this study builds on promising early data in schizophrenia.
Where this research is happening
-
University of Manitoba
Winnipeg, Canada Active
Researchers
- Principal investigator: Mccleery, Amanda — University of Manitoba
- Study coordinator: Mccleery, Amanda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.