Predicting skin cancer risk using UV mutation signatures
Using Clonal and Non-Clonal UV Signature Mutations to Predict Skin Cancer Risk
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10667531
This study is looking at how certain changes in your skin caused by UV light can help figure out if you're at a higher risk for skin cancer, especially for people who are more likely to develop it, so we can find better ways to keep you safe and healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10667531 on ClinicalTrials.gov |
What this research studies
This research investigates how specific mutations caused by ultraviolet (UV) light can help predict an individual's risk of developing skin cancer. By focusing on high-risk populations, the study aims to utilize a novel skin biopsy technique to collect samples from non-diseased areas of the skin, allowing for a better understanding of past UV exposure and its effects. The goal is to enhance cancer prevention efforts by identifying individuals who may benefit from closer monitoring and intervention. This approach leverages recent advancements in molecular profiling to provide personalized risk assessments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of significant UV exposure or those with a family history of skin cancer.
Not a fit: Patients who have no history of UV exposure or skin cancer in their family may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective skin cancer prevention strategies tailored to individual risk profiles.
How similar studies have performed: Other research has shown promise in using genetic mutations for cancer risk prediction, making this approach both innovative and grounded in prior success.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRASH, DOUGLAS E — YALE UNIVERSITY
- Study coordinator: BRASH, DOUGLAS E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Cancer Causing Agents, Skin Cancer