Predicting severe leptospirosis and long-term kidney problems
Official title: Identification of predictive biomarkers for severe acute leptospirosis and its long-term sequelae
Funded at Chulalongkorn University · NIH-11394812 · Data updated 2026-11-12
This project looks for early biological signals that identify people with leptospirosis who will become severely ill and have lasting kidney trouble.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chulalongkorn University NIH-funded |
| Lab location | 1 site (Bangkok, THAILAND) |
| Project start | August 9, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $136,828 |
| NIH project number | 5R01AI183353-03 |
| Project ID | NIH-11394812 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with acute leptospirosis, especially in endemic regions, whose data and samples are available in the study’s biorepository and longitudinal cohort.
✕Less likely to help
Patients whose disease is mild or who do not contribute data to the biomarker discovery process may see no direct benefit.
What this research studies
Leptospirosis can cause severe illness with kidney failure and other organ damage, and current tests often miss who will get worse. The study will use patient samples, existing biorepository, and long-term follow-up data from infected individuals in Thailand to identify biomarkers that predict severe disease and future kidney problems. Researchers will apply previous biomarker discoveries and validated prediction tools to improve how clinicians identify high-risk patients early on. The goal is to guide timely treatment and reduce long-term kidney damage, benefiting patients with this infection and informing broader sepsis-related care.
Why it matters
Potential benefit: If successful, clinicians could predict which patients are at highest risk and tailor early interventions to prevent kidney injury and long-term complications.
How similar studies have gone: Previous multi-omics biomarker work and complete cohorts in endemic areas support a strong basis for identifying predictive markers, though exact predictors for severe leptospirosis remain to be validated.
Where this research is happening
-
Chulalongkorn University
Bangkok, Thailand Active
Researchers
- Principal investigator: Srisawat, Nattachai — Chulalongkorn University
- Study coordinator: Srisawat, Nattachai
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Finding biomarkers to predict severe leptospirosis and its long-term effects
This study is looking for ways to find signs in blood tests that can help doctors predict how serious leptospirosis might be for patients, so they can provide better care and support for those at risk of severe illness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.