Finding biomarkers to predict severe leptospirosis and its long-term effects
Official title: Identification of predictive biomarkers for severe acute leptospirosis and its long-term sequelae
Funded at Chulalongkorn University · NIH-10895606 · Data updated 2026-11-12
This study is looking for ways to find signs in blood tests that can help doctors predict how serious leptospirosis might be for patients, so they can provide better care and support for those at risk of severe illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chulalongkorn University NIH-funded |
| Lab location | 1 site (Bangkok, THAILAND) |
| Project start | August 9, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $137,229 |
| NIH project number | 1R01AI183353-01 |
| Project ID | NIH-10895606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with leptospirosis, particularly those experiencing severe symptoms.
✕Less likely to help
Patients with mild leptospirosis or those who have not been diagnosed with the disease may not benefit from this research.
What this research studies
This research investigates how to identify biomarkers that can predict the severity of leptospirosis, a serious infectious disease. By analyzing blood samples and clinical data from patients, researchers aim to develop methods to foresee which individuals are at risk of severe complications. The study employs advanced machine learning techniques to refine the identification of these biomarkers, which could lead to better patient management and outcomes. The research will utilize existing patient samples and recruit new participants for comprehensive analysis.
Why it matters
Potential benefit: If successful, this research could lead to earlier interventions for patients at risk of severe leptospirosis, potentially reducing mortality and long-term health complications.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for infectious diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Chulalongkorn University
Bangkok, Thailand Active
Researchers
- Principal investigator: Srisawat, Nattachai — Chulalongkorn University
- Study coordinator: Srisawat, Nattachai
Related research
Other NIH-funded projects on the same topics.
-
Predicting severe leptospirosis and long-term kidney problems
This project looks for early biological signals that identify people with leptospirosis who will become severely ill and have lasting kidney trouble.
-
Integrated public health and academic collaboration for infectious disease control
A Thai–US partnership is building better surveillance and lab systems to detect and respond to infectious diseases, while also supporting adolescent HIV prevention.
-
Blood markers to predict severe and long-term effects of leptospirosis
Looking for blood markers that predict which people with leptospirosis will become seriously ill or develop long-term problems.
-
One Health partnership to strengthen outbreak detection and protect adolescents from HIV in Thailand
This project builds a national One Health network in Thailand to find new infectious threats quickly and improve HIV prevention for adolescents.
-
Collaboration for controlling infectious diseases and preventing adolescent HIV
This study is working to improve how we respond to infectious diseases in Thailand by bringing together health and academic groups to better track and manage outbreaks, while also using new technology to identify viruses and help prevent HIV in teenagers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.