Predicting heart disease risk in young male veterans with erectile dysfunction
Official title: Polygenic Risk Stratification for Cardiovascular Disease in Young Male Veterans presenting with Erectile Dysfunction
Funded at VA San Diego Healthcare System · NIH-11206878 · Data updated 2026-11-12
This project uses genetic risk scores and medical records to find which young male veterans with erectile dysfunction are most likely to have future heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2029 |
| Funding year | 2026 |
| NIH project number | 5IK2BX006522-02 |
| Project ID | NIH-11206878 on NIH RePORTER |
Who could benefit from this research
✓Could help
Young male U.S. veterans with erectile dysfunction, especially those enrolled in the Million Veterans Program or receiving care in the VA system, are the ideal candidates.
✕Less likely to help
Women, non-veterans, people without ED, or individuals without VA medical records or genetic data are unlikely to be included or to get direct benefit from this work.
What this research studies
You and other veterans with erectile dysfunction would have your VA health records and genetic data reviewed to see how other medical conditions group together with ED. Researchers will group men with ED into subtypes based on other health problems using clustering of big data from the Million Veterans Program. They will use genetic studies and polygenic risk scores, plus Mendelian randomization methods, to explore whether traits like diabetes or depression help cause both ED and heart disease. The goal is to build a genetics-informed tool to better predict who needs stronger heart-protecting care.
Why it matters
Potential benefit: Could help identify which men with ED should get earlier or more intensive heart disease prevention to lower their risk of heart attacks.
How similar studies have gone: Genetic risk scores and GWAS have helped predict cardiovascular risk in other groups, but applying clustering and causal genetic methods specifically to men with ED is a newer approach.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Patel, Darshan Prahlad — VA San Diego Healthcare System
- Study coordinator: Patel, Darshan Prahlad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.