NIH-funded research NIH-funded research

Predicting heart disease risk in young male veterans with erectile dysfunction

Official title: Polygenic Risk Stratification for Cardiovascular Disease in Young Male Veterans presenting with Erectile Dysfunction

Funded at VA San Diego Healthcare System · NIH-11206878 · Data updated 2026-11-12

This project uses genetic risk scores and medical records to find which young male veterans with erectile dysfunction are most likely to have future heart problems.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionVA San Diego Healthcare System
NIH-funded
Lab location1 site (San Diego, United States)
Project startOctober 1, 2024
Project endSeptember 30, 2029
Funding year2026
NIH project number5IK2BX006522-02
Project IDNIH-11206878 on NIH RePORTER

Who could benefit from this research

Could help

Young male U.S. veterans with erectile dysfunction, especially those enrolled in the Million Veterans Program or receiving care in the VA system, are the ideal candidates.

Less likely to help

Women, non-veterans, people without ED, or individuals without VA medical records or genetic data are unlikely to be included or to get direct benefit from this work.

What this research studies

You and other veterans with erectile dysfunction would have your VA health records and genetic data reviewed to see how other medical conditions group together with ED. Researchers will group men with ED into subtypes based on other health problems using clustering of big data from the Million Veterans Program. They will use genetic studies and polygenic risk scores, plus Mendelian randomization methods, to explore whether traits like diabetes or depression help cause both ED and heart disease. The goal is to build a genetics-informed tool to better predict who needs stronger heart-protecting care.

Why it matters

Potential benefit: Could help identify which men with ED should get earlier or more intensive heart disease prevention to lower their risk of heart attacks.

How similar studies have gone: Genetic risk scores and GWAS have helped predict cardiovascular risk in other groups, but applying clustering and causal genetic methods specifically to men with ED is a newer approach.

Where this research is happening

  • VA San Diego Healthcare System
    San Diego, United States
    Active

Researchers

  • Principal investigator: Patel, Darshan Prahlad — VA San Diego Healthcare System
  • Study coordinator: Patel, Darshan Prahlad

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.