Precision ventilation to reduce ventilator-caused lung injury
2/2: PREcision VENTilation to attenuate Ventilation-Induced Lung Injury (PREVENT VILI)
This project looks to see if a tailored ventilator approach that limits driving pressure and adjusts PEEP helps adults with moderate or severe ARDS survive better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11182556 on NIH RePORTER |
What this research studies
If you have ARDS and are on a breathing machine, this trial compares a precision ventilator method that keeps driving pressure ≤12 cm H2O and sets PEEP by transpulmonary pressure (around 0±2 cm H2O) versus guided usual care. It is a multicenter, prospective phase III randomized trial enrolling adults with moderate or severe ARDS and following outcomes including 60-day mortality. A Data Coordinating Center at Beth Israel Deaconess will manage data, quality control, and logistics across participating hospitals. The aim is to reduce ventilator-induced lung injury and improve survival by using more precise ventilator settings.
Who could benefit from this research
Good fit: Adults age 21 or older with moderate to severe ARDS who are receiving mechanical ventilation and meet the trial's clinical entry criteria would be ideal candidates.
Not a fit: People with mild ARDS, children, patients not on mechanical ventilation, or those who do not meet enrollment criteria would likely not benefit from this trial.
Why it matters
Potential benefit: If successful, this strategy could lower ventilator-related lung injury and reduce 60-day mortality for adults with moderate or severe ARDS.
How similar studies have performed: Lower tidal-volume and driving-pressure approaches have shown promise in prior studies, but this exact precision ventilation combination has not yet been proven in a large phase III trial.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Baedorf Kassis, Elias — Beth Israel Deaconess Medical Center
- Study coordinator: Baedorf Kassis, Elias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.