Precision tapering of dupilumab in asthma to reduce dose while keeping control
Official title: 2/2 Precision Tapering of Biological Therapy in Asthma: Identifying Predictors of Optimized Dupilumab Dosing
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11436197 · Data updated 2026-11-12
This grant tests whether adults with well-controlled asthma on dupilumab can safely extend dosing intervals to save costs while keeping symptoms in check.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | September 15, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $580,981 |
| NIH project number | 1U24HL188704-01 |
| Project ID | NIH-11436197 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) with severe asthma who are well controlled on dupilumab plus controller therapy.
✕Less likely to help
Patients who are not well controlled on dupilumab or who have unstable asthma may not benefit from tapering.
What this research studies
For adults with severe asthma already well controlled on dupilumab and standard therapy, the study will compare continuing every 2 weeks versus extending to every 4 weeks for 48 weeks in a pragmatic trial. A second re-randomization will explore even longer intervals for those who remain controlled. Researchers will look at clinical signs, lung function, and biological markers to identify predictors of successful tapering. The goal is to determine safe, value-based dosing strategies that maintain control and reduce treatment burden.
Why it matters
Potential benefit: If successful, patients could experience similar asthma control with fewer injections and lower overall treatment costs.
How similar studies have gone: Similar tapering approaches have shown promise in other biologics, but this study will identify predictors specific to dupilumab in asthma.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Mauger, David T. — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Mauger, David T.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.