Precision breathing support to reduce ventilator-related lung injury
1/2: PREcision VENTilation to attenuate Ventilation-Induced Lung Injury (PREVENT VILI)
This project will try personalized ventilator settings to reduce lung damage in adults with ARDS who need mechanical ventilation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11187148 on NIH RePORTER |
What this research studies
If you have severe ARDS and need a breathing machine, doctors would tailor how the ventilator delivers breaths to your lungs rather than using a one-size-fits-all setting. Care teams will use measurements of how much lung is actually aerated and how the lung responds to pressure to guide tidal volume and PEEP choices. The goal is to avoid both overinflating parts of the lung and repetitive opening and closing of lung units that can cause extra injury. This work would take place in the ICU while patients are receiving standard life-sustaining care.
Who could benefit from this research
Good fit: Adults (21+) with moderate to severe ARDS who require invasive mechanical ventilation in participating ICUs are the intended candidates.
Not a fit: People who do not require mechanical ventilation, have only mild respiratory failure, or have conditions that prevent protocolized ventilator adjustments may not benefit or be eligible.
Why it matters
Potential benefit: If successful, this approach could reduce ventilator-caused lung injury, improve survival, and lessen long-term physical and cognitive problems after ARDS.
How similar studies have performed: Prior trials showed that low tidal volume ventilation reduces ARDS mortality and some physiologic-guided methods are promising, but fully individualized precision ventilation remains an emerging strategy.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Talmor, Daniel Stuart — Beth Israel Deaconess Medical Center
- Study coordinator: Talmor, Daniel Stuart
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.