NIH-funded research R01 grant

Powered knee and ankle prosthetics for K2-level transfemoral amputees

Official title: Understanding how Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

Funded at Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab · NIH-11336405 · Data updated 2026-11-12

A study tests lightweight, fully powered knee and ankle devices to help people with a transfemoral amputation at K2 level move more easily and efficiently.

More Gait research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionRehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
NIH-funded
Lab location1 site (Chicago, United States)
Project startJuly 1, 2023
Project endJune 30, 2028
Funding year2026
Award (this year)$674,741
NIH project number5R01HD108554-04
Project IDNIH-11336405 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates are adults with unilateral transfemoral amputation currently prescribed passive prostheses and classified as K2-level ambulators.

Less likely to help

Participants with higher or lower activity levels than K2, or those with contraindications to powered devices, may not experience the same benefits.

What this research studies

The project will test lightweight powered knee and ankle components that can be used alone or together to see how they affect energy use, gait, and everyday mobility in people with a unilateral above-knee amputation who normally use a passive prosthesis. Researchers will compare outcomes when using knee power, ankle power, or both, considering the extra weight and control needs. Twenty K2-level participants will be recruited and asked to perform tasks like stairs, ramps, and sit-to-stand to measure metabolic cost and functional performance. The goal is to identify benefits and tradeoffs of powered components for this group and guide future design and prescription.

Why it matters

Potential benefit: If successful, powered components could improve mobility and reduce effort for K2-level amputees, expanding functional options and comfort.

How similar studies have gone: Prior research suggests powered components can improve function in higher-level ambulators; this study explores benefits specifically for K2-level users.

Where this research is happening

  • Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
    Chicago, United States
    Active

Researchers

  • Principal investigator: Hargrove, Levi John — Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
  • Study coordinator: Hargrove, Levi John

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.