Posttranscriptional Regulation of ozone-induced lung inflammation
Official title: Posttranscriptional Regulation of environmental pollutants-induced lung inflammation
Funded at North Carolina State University Raleigh · NIH-11443051 · Data updated 2026-11-12
This research explores how the body’s own regulators control harmful lung inflammation caused by ozone exposure, with potential implications for treating people with respiratory conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $713,091 |
| NIH project number | 1R01HL187922-01 |
| Project ID | NIH-11443051 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with acute or allergic lung conditions who may benefit from therapies targeting inflammatory pathways, or people with prior ozone exposure risk in urban settings.
✕Less likely to help
Healthy individuals without lung disease or those not exposed to ozone-related risk may have limited direct benefit.
What this research studies
This project looks at how a protein called Tristetraprolin (TTP) controls inflammation in the lungs after ozone exposure. By studying this mechanism in the context of acute lung injury and allergic inflammation, the team aims to identify ways to boost anti-inflammatory responses and help the lungs heal. The study will use models that reflect how humans respond to ozone and focus on pathways that promote resolution of inflammation. The goal is to find therapeutic ideas that reduce tissue damage and improve recovery after environmental lung insults.
Why it matters
Potential benefit: If successful, the work could lead to new strategies to reduce ozone-driven lung inflammation and improve outcomes for people with asthma or other lung diseases exposed to air pollutants.
How similar studies have gone: Previous studies suggest that modulating inflammatory regulators can influence lung injury outcomes, supporting potential benefit of this approach.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Saini, Yogesh — North Carolina State University Raleigh
- Study coordinator: Saini, Yogesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.