Post-TB lung disease in HIV patients: how common and what it looks like over time
Official title: The SEQUELAE TB Study: A Systematic Evaluation of the QUantifiable Effects of HIV on the prevaLence, phenotypes, severity, And trEatable traits of post-TB lung disease
Funded at University of California, San Francisco · NIH-11581281 · Data updated 2026-11-12
This study looks at how many people who survived TB have ongoing lung problems, what kinds of problems they are, and how HIV might change them, in a large group followed after TB treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $292,815 |
| NIH project number | 3R01AI197964-01A1S1 |
| Project ID | NIH-11581281 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and adolescents aged 15 years and older who have completed TB treatment, with and without HIV, in Lusaka, Zambia.
✕Less likely to help
Patients without HIV or those not experiencing PTLD may not derive direct benefit from the findings.
What this research studies
Researchers will follow a cohort of TB survivors in Lusaka, Zambia, to describe how common post-TB lung disease is, what shapes its presentation (such as obstructive patterns, bronchiectasis, or fibrosis), and how severe it remains over 18 months after TB treatment ends. They will also compare results to a control group without TB to see baseline lung disease rates. The study will stratify findings by HIV status to understand potential modification by HIV infection. Data collection will include imaging and lung function assessments to identify potentially treatable traits that could guide future care. The ultimate goal is to improve diagnosis and management of PTLD in people affected by TB, including those living with HIV.
Why it matters
Potential benefit: Patients could receive better understanding of PTLD patterns and potential targets for treatment, leading to earlier diagnosis and improved management.
How similar studies have gone: Prior work has shown PTLD is common among TB survivors, but this study aims to characterize phenotypes and HIV interactions in detail within a defined cohort.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kerkhoff, Andrew — University of California, San Francisco
- Study coordinator: Kerkhoff, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.