Platinum-based countermeasures to treat cyanide poisoning and protect people
Official title: Platinum Based Countermeasures and Combinations with Protective Agents
Funded at Purdue University · NIH-11416483 · Data updated 2026-11-12
Aimed at developing safer, more effective platinum-based treatments and protective agents to rescue people from cyanide poisoning in emergencies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $727,820 |
| NIH project number | 4UH3NS134957-03 |
| Project ID | NIH-11416483 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people at risk of cyanide exposure or populations that could benefit from rapid antidote development and subsequent clinical trials.
✕Less likely to help
This research is conducted in animal models and early development stages, so it would not directly benefit patients at this time.
What this research studies
This project tests new platinum(II)-based countermeasures in three animal models to find a fast, reliable way to reverse cyanide poisoning. Researchers will focus on choosing developable compounds and testing them alone and in combination with protective agents to improve survival and reduce long-term harm. The work includes medicinal chemistry, pharmacology, toxicology, and in vivo screening to select the best candidates for potential human use. If successful, these countermeasures could be deployed in high-risk scenarios such as chemical incidents to improve outcomes for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to safer, more effective treatments for cyanide exposure that save lives and reduce lasting injuries.
How similar studies have gone: Previous studies in similar domains have shown the promise of metal-based countermeasures, but this project advances toward developable, next-generation candidates.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Davisson, Vincent Jo — Purdue University
- Study coordinator: Davisson, Vincent Jo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.