Pilot Projects for Patient-Docused Cancer Models (PDX/PDO) Core
Official title: Pilot Projects and Trans-Network Activities Core
Funded at Virginia Commonwealth University · NIH-11580907 · Data updated 2026-11-12
A core at Virginia Commonwealth University will quickly expand the use of patient-derived tumor models to support translational cancer research aimed at reducing cancer burden in patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | July 19, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $25,375 |
| NIH project number | 5U54CA283762-04 |
| Project ID | NIH-11580907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancer who contribute tumor tissue or data for research and may benefit from future tailored therapies.
✕Less likely to help
Some patients' tumors or data may not be used in the selected pilot projects or may not lead to immediate benefit.
What this research studies
This grant funds a core that expedites the use of PDX and PDO models within the institution and its partners. It selects two one-year pilot projects—one using locally generated models and one using trans-network collaborations with other PDXNet members—to advance translational cancer research. The core also builds connections with the Administrative Core and PDXNet to foster longer-term, resource-sharing collaborations. The overall goal is to develop teams and workflows that can translate model findings into real-world patient benefits.
Why it matters
Potential benefit: If successful, patients could see faster development of targeted cancer therapies informed by patient-derived tumor models.
How similar studies have gone: Other programs using PDX/PDO models have advanced translational cancer research, with several groups reporting improved understanding of treatment responses.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Sarkar, Devanand — Virginia Commonwealth University
- Study coordinator: Sarkar, Devanand
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.