Photon-efficient fluorescence imaging to study multiple signals in cells
Official title: Photon-Efficient Spectral Lifetime Microscopy
Funded at Salk Institute for Biological Studies · NIH-11430253 · Data updated 2026-11-12
A high-tech imaging project to visualize many different cellular signals at once using advanced light-smart microscopy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | August 10, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $475,249 |
| NIH project number | 1R35GM166021-01 |
| Project ID | NIH-11430253 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are researchers and laboratories using fluorescence microscopy to study cellular signaling and disease-related biology.
✕Less likely to help
Direct patient participation is not described in this grant; the work is primarily methodological development.
What this research studies
This grant aims to develop new fluorescence microscopy methods that let scientists track many molecular signals inside living cells at the same time, using photon-efficient lifetime and spectral imaging. By pushing the limits of how much information can be captured per photon, it will provide clearer, more detailed pictures of how cellular components communicate. The work combines innovative optical technology with rigorous testing to determine how many signals and interactions can be resolved in complex cell environments.
Why it matters
Potential benefit: If successful, patients could benefit from faster, more precise insights into cellular processes that drive health and disease, informing future diagnostics and therapies.
How similar studies have gone: Previous imaging methods improved through advanced optics; this project seeks to exceed current multiplexing limits and remains at the technology-development stage.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Bowman, Adam Joseph — Salk Institute for Biological Studies
- Study coordinator: Bowman, Adam Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.