PhenX Toolkit as a biomedical knowledgebase to harmonize data
Official title: Establishing the PhenX Toolkit as a Biomedical Knowledgebase
Funded at Research Triangle Institute · NIH-11415006 · Data updated 2026-11-12
A large NIH project is building a freely accessible collection of standard measurement protocols to help researchers collect consistent data across studies and improve patient care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | September 20, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,517,877 |
| NIH project number | 5U24HG012556-05 |
| Project ID | NIH-11415006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and clinicians conducting human participants research who need standardized measurement protocols and data harmonization.
✕Less likely to help
Patients are not directly enrolled in this grant; benefits come through improved research quality and future therapies.
What this research studies
This grant supports expanding the PhenX Toolkit, a web-based catalog of measurement protocols, to become a comprehensive biomedical knowledgebase. The goal is to enable researchers to use common tools—surveys, bioassays, and physical measurements—so data from different studies can be combined and compared more easily. The effort emphasizes community input and consensus to ensure the protocols are applicable to genomic, clinical, translational, and epidemiological research involving human participants. Over the next several years, the project will increase the toolkit’s breadth and utility to enhance understanding of disease causes, progression, and treatment, ultimately improving patient outcomes. The work is led by a team at the Research Triangle Institute under an NIH U24 cooperative agreement mechanism.
Why it matters
Potential benefit: If successful, patients could benefit from more reliable research findings, faster validation of new diagnostics and treatments, and improved quality of life through better-informed medical decisions.
How similar studies have gone: Previous PhenX work established a broad catalog of protocols and has informed many studies, with ongoing expansion to cover more domains.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Hamilton, Carol Marie — Research Triangle Institute
- Study coordinator: Hamilton, Carol Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.