PGC-1 alpha in Lung Immune Response against Pseudomonas infections
Official title: PGC-1 alpha in Lung Immune Response
Funded at Omaha VA Medical Center · NIH-11264894 · Data updated 2026-11-12
Aims to understand how a key cellular regulator helps the lung fight off tough bacterial infections that are hard to treat.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Omaha VA Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | July 1, 2013 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| NIH project number | 5I01BX001786-13 |
| Project ID | NIH-11264894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with or at risk of pneumonia or lung infections caused by drug-resistant Pseudomonas aeruginosa, particularly those with compromised immunity.
✕Less likely to help
Patients without lung infection or those not affected by Pseudomonas-related disease may not benefit from this research.
What this research studies
This project looks at how the body’s energy-regulating pathways influence lung immunity when facing Pseudomonas aeruginosa, a dangerous drug-resistant bacterium. Researchers previously found that certain lipid signals and the PPARγ pathway affect lung defenses and that these defenses can be boosted by specific activators. The work will explore how PGC-1α and related mitochondrial factors control the lung’s response to bacterial virulence factors and may identify new ways to strengthen host defenses. Outcomes could point to therapies that enhance patient resilience to severe infections in hospitalized or immunocompromised individuals.
Why it matters
Potential benefit: If successful, the work could lead to new approaches that boost lung immune defenses and improve outcomes for patients with drug-resistant lung infections.
How similar studies have gone: Previous findings support a link between mitochondrial regulation and lung immunity, suggesting this line of work has promising potential but remains exploratory.
Where this research is happening
-
Omaha VA Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Sadikot, Ruxana T — Omaha VA Medical Center
- Study coordinator: Sadikot, Ruxana T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.