LHCGR signaling in aging ovaries and its implications for fertility
Official title: LHCGR signaling and responses during ovarian aging
Funded at Omaha VA Medical Center · NIH-11300896 · Data updated 2026-11-12
Aiming to understand how aging affects hormonal signaling in ovaries to inform better care for women facing infertility.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Omaha VA Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | April 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| NIH project number | 1I01RD001510-01A2 |
| Project ID | NIH-11300896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women in reproductive age, including veterans, whose ovarian aging or infertility may be linked to LHCGR signaling.
✕Less likely to help
Patients without ovarian aging-related infertility or without access to VA fertility services may not benefit directly.
What this research studies
This project studies how aging changes the way luteinizing hormone/hCG receptor (LHCGR) signals in ovarian cells, using samples from young and older women and mouse models. Researchers will examine chromatin accessibility and gene regulation with ATAC-seq to see how aging alters responses to hormonal triggers. The goal is to identify mechanisms that contribute to infertility in aging ovaries and to point toward potential therapeutic targets for preserving fertility in women and veterans affected by infertility.
Why it matters
Potential benefit: If successful, findings could lead to new strategies to maintain or restore fertility in aging women, including veterans facing infertility.
How similar studies have gone: Previous studies have shown that hormonal signaling pathways change with age, but direct links to LHCGR signaling in aging ovaries are still being explored.
Where this research is happening
-
Omaha VA Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Davis, John S — Omaha VA Medical Center
- Study coordinator: Davis, John S
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Biological aging across the lifespan through a national high school-to-adult study
This grant uses a long-running national study of students and adults to collect saliva biomarkers of aging, alongside surveys, to understand how aging markers relate to health and life experiences.
-
Understanding how aging and Alzheimer’s affect how people make tough choices
This NIH grant studies how aging and Alzheimer’s risk change how people decide between immediate and delayed rewards and risky options, with the goal of helping older adults stay financially and healthwise safer.
-
Understanding how brain resilience and multiple brain pathologies influence aging and Alzheimer's disease
A long-term study follows older adults to learn how resilience to brain changes helps reduce dementia risk and what biological factors are linked to better cognitive aging.
-
National Neighborhood Data Archive helps researchers study aging health in U.S. neighborhoods
A nationwide data resource will help researchers understand how where people live affects health and aging, with a focus on respiratory illnesses in older adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.