Personalized treatment approach for children with Sjögren's disease
Planning a childhood sJOgren disease Use of Randomized N-of-1 Evaluation of therapY JOURNEY
This project uses personalized N-of-1 trials to find which treatments work best for children with Sjögren's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11170767 on NIH RePORTER |
What this research studies
As a parent or child participant, you'll help create child- and parent-centered measures that capture gland inflammation, dryness flares, and impacts on daily life and mental health. The team will use N-of-1 trials, which involve short, repeated treatment periods tailored to each child, to see how individual children respond to therapies over time. The grant work will finalize a rigorous clinical N-of-1 protocol and the outcome tools needed to run future pediatric trials. This aims to make it clearer when a flare happens and whether a given treatment helps your child.
Who could benefit from this research
Good fit: Children diagnosed with childhood Sjögren's disease who have salivary or lacrimal gland inflammation and whose families can report symptoms and attend visits are ideal candidates.
Not a fit: Adults, children without glandular inflammation or flares, and families unable to participate in repeated treatment periods or symptom reporting are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this could help identify effective treatments for individual children and improve measurement of flares and quality of life.
How similar studies have performed: N-of-1 trial methods have shown promise in other chronic conditions, but applying them and new outcome measures specifically to childhood Sjögren's is a new approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Singer, Nora — Case Western Reserve University
- Study coordinator: Singer, Nora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.