Personalized Intubation Safety for Sick Neonates
Official title: Optimizing Tracheal Intubation Outcomes and Neonatal Safety (OPTION SAFE)
Funded at Children's Hosp of Philadelphia · NIH-11380804 · Data updated 2026-11-12
A new approach helps doctors safely manage breathing tube placement in critically ill newborns, aiming to reduce complications and improve outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $698,802 |
| NIH project number | 5R01HD106996-05 |
| Project ID | NIH-11380804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are infants in NICUs who require tracheal intubation and are at risk for airway-related complications.
✕Less likely to help
Very preterm infants or those not undergoing intubation may not directly benefit from this bundle.
What this research studies
This project tests a Safety Bundle called PINS to guide safer tracheal intubation in newborns across several NICUs. It builds on existing registry data to tailor interventions based on patient risk, provider skill, premedication, and use of video laryngoscopy. The study uses a pragmatic stepped-wedge design across eight NICUs to see if introducing the bundle lowers adverse events during intubation. Outcomes include adverse TI events, severe TI events, and extubation outcomes, with plans to monitor safety and effectiveness in real-world settings. If successful, the bundle could become a standard for reducing harm during neonatal airway management.
Why it matters
Potential benefit: If successful, the Safety Bundle could reduce harm and improve survival for newborns needing breathing support in the NICU.
How similar studies have gone: Previous pilot testing showed a 66% reduction in severe adverse events with the prototype Safety Bundle in a single center.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Foglia, Elizabeth — Children's Hosp of Philadelphia
- Study coordinator: Foglia, Elizabeth
Related research
Other NIH-funded projects on the same topics.
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IVOS Medical: Intubation, Optimized.
A small NIH-funded project aims to improve endotracheal intubation, a life-saving airway procedure, by making it safer and more reliable for adults in emergency and critical care settings.
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Pre-intubation checklist to make emergency breathing tube placement safer for injured children
Using a pre-intubation checklist and support tools to help emergency teams place breathing tubes more safely in children after traumatic injury.
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Improved breathing tube placement
This project is creating a better video tool to help doctors place breathing tubes more quickly and safely for adults needing emergency or surgical airway care.
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Safer breathing tube placement for newborns in the NICU
This project uses a personalized safety bundle to try to reduce complications when placing breathing tubes in critically ill newborns in neonatal intensive care units.
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A new endotracheal tube with optical sensors to improve intubation safety
This study is testing a new type of breathing tube that has special sensors to help doctors place it correctly and keep an eye on it during procedures, making it safer for patients who need help breathing.
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Improving the safety and effectiveness of emergency intubation procedures.
This study is looking at ways to make it easier and safer for doctors to use a special camera tool during emergency intubation, by creating a disposable cover that keeps the camera clean, so patients can have better care when they need it most.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.