Personalized endovascular devices for brain aneurysms using 3D printing and shape memory polymers
Official title: Improving outcomes in endovascular treatment of intracranial aneurysms: Combining additive manufacturing, in-silico modeling, and shape memory polymers
Funded at University of California Riverside · NIH-11374830 · Data updated 2026-11-12
A new approach uses 3D-printed, patient-specific devices to treat brain aneurysms with the goal of improving long-term outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | August 23, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $615,275 |
| NIH project number | 5R01HL159475-05 |
| Project ID | NIH-11374830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with intracranial aneurysms at risk of rupture or those who have been treated with coil embolization but need improved, durable occlusion.
✕Less likely to help
Patients with aneurysms not suitable for personalized devices or those not undergoing endovascular therapy may not benefit.
What this research studies
This project aims to create custom embolic devices for brain aneurysms using additive manufacturing and biocompatible shape memory polymers, tailored to each patient’s aneurysm geometry. It combines physical testing with computer simulations to compare how well the devices perform against current techniques. The work focuses on translating lab findings into designs that could reduce recurrence and improve occlusion in people who have aneurysms or subarachnoid hemorrhage. By collaborating across biomechanics and hemodynamics, the research seeks to identify devices that stay in place and promote durable treatment.
Why it matters
Potential benefit: If successful, patients could experience more durable aneurysm occlusion and reduced need for re-treatment.
How similar studies have gone: Prior studies show promise for patient-specific devices, but this project aims to extend durability and occlusion rates with innovative materials.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Lee, Chung-Hao — University of California Riverside
- Study coordinator: Lee, Chung-Hao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.