Personalized antibiotic dosing for children with multiple organ dysfunction
Assessment of MODS and Personalized Exposures of Antibiotics
This project will see if tailoring antibiotic doses to each child’s biology helps children with MODS reach the right drug levels faster.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11143033 on NIH RePORTER |
What this research studies
This project uses blood samples and clinical data from 400 children with MODS enrolled in the ongoing PARADIGM study across 22 hospitals to measure how antibiotics behave in their bodies. Researchers will measure antibiotic levels over time (pharmacokinetics) and relate those levels to each child’s immune status and clinical course, including immune paralysis. The team will build models to identify when standard doses miss targets and to suggest personalized dosing strategies. Findings are intended to help guide doctors on dosing choices for critically ill children with infection and MODS.
Who could benefit from this research
Good fit: Ideal candidates are critically ill children with multiple organ dysfunction who are treated at one of the participating hospitals and enrolled in the PARADIGM study.
Not a fit: Children without MODS, those not hospitalized at a participating center, or those not infected are unlikely to be eligible or to directly benefit from this work.
Why it matters
Potential benefit: Could help doctors select antibiotic doses that reach effective and safe levels sooner, potentially reducing complications and deaths in children with MODS.
How similar studies have performed: Personalized antibiotic dosing has improved drug exposure and outcomes in some adult and pediatric ICU settings, but applying these methods specifically to children with MODS is largely new.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Downes, Kevin James — Children's Hosp of Philadelphia
- Study coordinator: Downes, Kevin James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.