Paternal e-cigarette exposure and its effect on blood clots
Official title: The Mechanistic Impact of Paternal Electronic Nicotine Delivery Systems Exposure on Thrombogenesis
Funded at Texas A&m University Health Science Ctr · NIH-11416632 · Data updated 2026-11-12
This grant studies whether a father’s use of e-cigarettes or vaping products before conception can affect his children and increase the risk of blood clots in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | July 1, 2019 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $739,833 |
| NIH project number | 5R01HL145053-07 |
| Project ID | NIH-11416632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with a history of ENDS exposure who may be considering fatherhood or who have a family history of thrombotic disorders, though this study centers on preclinical models.
✕Less likely to help
People without exposure history or those seeking immediate clinical treatments for cardiovascular disease may not directly benefit.
What this research studies
Researchers will explore how exposure of potential fathers to ENDS (e-cigarettes and electronic waterpipes) may influence father’s sperm and offspring blood biology, focusing on blood clotting, platelet function, and inflammatory states. The project uses animal models and translational approaches to understand mechanisms such as changes in platelet genes and epigenetic marks that could be passed to offspring. It will examine sex-specific effects and how paternal ENDS exposure might alter normal hemostasis and the risk of thrombosis. The work aims to connect basic biology with potential clinical implications for cardiovascular health across generations.
Why it matters
Potential benefit: If successful, this work could help explain a potential inherited risk of blood clotting problems related to paternal vaping and guide preventive strategies.
How similar studies have gone: Some preclinical studies have shown paternal exposures can influence offspring biology, but direct links to ENDS and thrombosis are still emerging.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Khasawneh, Fadi T — Texas A&m University Health Science Ctr
- Study coordinator: Khasawneh, Fadi T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.