PAS proteins: How signaling switches work in cells
Official title: PAS proteins: Study and application of signaling mechanisms
Funded at Advanced Science Research Center · NIH-11359593 · Data updated 2026-11-12
A scientist team is studying PAS domains to understand how cells sense and respond to changes, with potential uses in medicine and biotechnology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Advanced Science Research Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $489,800 |
| NIH project number | 5R35GM156296-02 |
| Project ID | NIH-11359593 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-facing trial; this is a basic science grant. Patients are not required to participate.
✕Less likely to help
No direct patient involvement expected in this stage; the research is mechanistic.
What this research studies
This project looks at PAS domains that control many cellular activities and how their activity can be switched by different stimuli, including light. By mapping how these proteins change shape and interact with partners, researchers aim to uncover how normal signaling goes wrong in disease. The work combines biochemistry, biophysics, and biotechnology approaches to reveal mechanism and potential ways to control these proteins with small molecules or light. Insights could inform new therapies and smarter bioengineering tools that rely on cellular sensing systems.
Why it matters
Potential benefit: Better understanding of cellular sensing could lead to new disease therapies and smarter tools for biotechnology.
How similar studies have gone: Other PAS-domain studies have shown how ligand binding and light can control protein activity, suggesting meaningful progress could come from this work.
Where this research is happening
-
Advanced Science Research Center
New York, United States Active
Researchers
- Principal investigator: Gardner, Kevin H — Advanced Science Research Center
- Study coordinator: Gardner, Kevin H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.