Investigating how environmental factors affect brain cell development.
Official title: Environmental Biosensors in the Oligodendrocyte Lineage
Funded at Advanced Science Research Center · NIH-11067780 · Data updated 2026-11-12
This study is looking at how certain brain cells that help keep our brains healthy grow and change, which could help us understand and find new treatments for conditions like depression and multiple sclerosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Advanced Science Research Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 15, 2019 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,158,744 |
| NIH project number | 5R35NS111604-07 |
| Project ID | NIH-11067780 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults experiencing neurological or psychiatric disorders, particularly those related to myelination issues.
✕Less likely to help
Patients with conditions unrelated to myelination or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding how myelinating glial cells, which are crucial for brain health, develop from progenitor cells in both the developing and adult brain. The team is exploring the basic mechanisms that regulate this process, particularly how epigenetic changes influence cell differentiation. By using animal models and advanced biosensors, they aim to uncover the links between environmental factors, brain function, and potential neurological disorders. The findings could lead to new therapeutic strategies for conditions like depression and multiple sclerosis.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for psychiatric and neurological disorders linked to myelination impairments.
How similar studies have gone: Previous research has shown promising results in understanding myelination and its implications for brain health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Advanced Science Research Center
New York, United States Active
Researchers
- Principal investigator: Casaccia, Patrizia — Advanced Science Research Center
- Study coordinator: Casaccia, Patrizia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.