Partnership to Understand Virus-and-Immune Factors in HIV-Associated Cancers
Official title: Partnership to Assess Viral and Immune Landscape Intersections with ONcology for People Living with HIV (PAVILION)
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11535248 · Data updated 2026-11-12
A multi-site project will study how viruses, the immune system, and cancer interact in people living with HIV to improve prevention, detection, and treatment of AIDS-related cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 3, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $224,139 |
| NIH project number | 3U54CA277834-04S2 |
| Project ID | NIH-11535248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV who are at risk for or have AIDS-related malignancies, including HPV-related cancers and other virus-associated tumors.
✕Less likely to help
Patients without HIV or those not at risk for virus-associated cancers are unlikely to benefit directly.
What this research studies
This program brings together top HIV, HPV, EBV, and cancer researchers to look at virus-related cancers that affect people with HIV. The effort focuses on understudied tumors and aims to uncover how viral activity, immune responses, and clinical factors drive cancer risk and outcomes in PLWH. By collaborating across expert sites, the project intends to inform better strategies for prevention, early detection, and treatment of AIDS-related malignancies. It addresses disparities in cancer care and seeks findings that could guide future interventions for aging HIV populations.
Why it matters
Potential benefit: If successful, the project could lead to earlier cancer detection and more effective, tailored treatments for people living with HIV.
How similar studies have gone: This area builds on prior work showing links between viral infections, immune dysfunction, and cancer in HIV; the approach integrates multiple viruses and cancer types for broader impact.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Giuliano, Anna R. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Giuliano, Anna R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.