Oral HPV Research in Latin Americans Living with HIV
Official title: Oral HPV Research Among Latin Americans Living with HIV (ORAL - H² Study)
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11622559 · Data updated 2026-11-12
A study to understand how HPV-related oropharyngeal cancer develops in people living with HIV and what factors and biomarkers could help prevent or detect it early.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 12, 2022 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $179,115 |
| NIH project number | 3R01CA274950-05S2 |
| Project ID | NIH-11622559 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV who are at risk for or have exposure to oncogenic oral HPV, with interest in prevention and early detection.
✕Less likely to help
Individuals without HIV or those not at risk for oral HPV-related cancer may not benefit.
What this research studies
This project looks at how HPV infection in the mouth and throat may lead to cancer in people with HIV, focusing on Latin American communities. Researchers are identifying modifiable risk factors and easy-to-measure biomarkers to improve surveillance and prevention. The study builds on previous natural history work and ties to ongoing vaccine trials, aiming to inform who is at highest risk and how to detect problems earlier. It involves analyzing clinical data and biological samples to understand persistence of oral HPV and cancer risk. The goal is to help tailor prevention and early detection strategies for PLWH who are disproportionately affected.
Why it matters
Potential benefit: If successful, the study could improve early detection and prevention of HPV-related oropharyngeal cancer in people living with HIV, potentially saving lives.
How similar studies have gone: Previous work has contributed to understanding oral HPV natural history; this project aims to build on that with risk factors and biomarkers in PLWH.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Giuliano, Anna R. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Giuliano, Anna R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.