Oral HPV Research in Latin Americans Living with HIV
Official title: Oral HPV Research Among Latin Americans Living with HIV (ORAL - H² Study)
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11622558 · Data updated 2026-11-12
A study to understand how HPV-related oropharyngeal cancer develops in people living with HIV and to find ways to identify and prevent it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 12, 2022 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $109,004 |
| NIH project number | 3R01CA274950-05S1 |
| Project ID | NIH-11622558 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV who are at risk for oral HPV-related cancer, particularly older individuals with compromised oral health.
✕Less likely to help
People without HIV or those not at elevated risk for HPV-related oropharyngeal cancer may not benefit from these findings.
What this research studies
This project focuses on people living with HIV who are at higher risk for HPV-related throat cancers. It aims to uncover modifiable risk factors and biomarkers that help detect pre-cancer changes and inform targeted surveillance. Researchers are building on prior natural history studies of oral HPV to improve prevention strategies, including how age, oral health, and immune status influence cancer risk. The work will inform who should be watched more closely for early signs and how to tailor prevention efforts for high-risk groups.
Why it matters
Potential benefit: If successful, it could lead to better risk screening, earlier detection of pre-cancer lesions, and more effective prevention strategies for people with HIV.
How similar studies have gone: The team has conducted large oral HPV natural history studies and has ongoing trials on HPV vaccination for OPC prevention.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Giuliano, Anna R. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Giuliano, Anna R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.