Oral HPV Research in Latin Americans Living with HIV
Official title: Oral HPV Research Among Latin Americans Living with HIV (ORAL - H² Study)
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11419763 · Data updated 2026-11-12
This study looks at how HPV-related oropharyngeal cancer risk can be understood and reduced among people living with HIV in Latin America.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 12, 2022 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $319,556 |
| NIH project number | 5R01CA274950-05 |
| Project ID | NIH-11419763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV who are of Latin American descent and at risk for HPV-related OPC.
✕Less likely to help
Individuals without HIV or not at risk for HPV-related OPC may not benefit directly.
What this research studies
This project aims to identify risk factors and biomarkers for human papillomavirus (HPV)–related oropharyngeal cancer (OPC) in people living with HIV, focusing on Latin American populations. Researchers will examine modifiable behaviors, immune factors, and other influences to find ways to improve early detection and prevention in high-risk groups. The study builds on prior natural history work and aligns with ongoing trials of the 9vHPV vaccine for OPC prevention, while exploring additional prevention strategies for those who may not access vaccination. Participation may involve providing health information, oral samples, and follow-up data to link risk profiles with OPC development. The ultimate goal is to inform targeted surveillance and prevention approaches for PLWH at greatest risk.
Why it matters
Potential benefit: Findings could lead to better screening and prevention strategies for OPC in people living with HIV, potentially reducing cancer risk.
How similar studies have gone: Previous studies have advanced understanding of oral HPV natural history, suggesting this approach could succeed in identifying high-risk groups.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Giuliano, Anna R. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Giuliano, Anna R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.